HOK的适应性再利用设计将美国圣路易斯Cortex科创社区内的一栋空置已久的砖砌仓库改建为多租户生物技术实验室和办公空间。
SEFA（美国科学仪器设备与实验室家具国际协会）年度实验室大奖旨在表彰创建杰出实验室建筑的团队。获奖的项目是在规划、设计和执行等各个方面都有出色表现的实验室。邓肯大街 4340号项目在2022年的评选中获得最高荣誉奖殊荣。
1930年建成的这座被列入美国国家史迹名录的新月大厦（现为邓肯大道4340号），曾是《圣路易斯快邮报》最先进的凹版印刷厂。
HOK的设计将这座老建筑改造成为能够为生物技术公司提供具有最先进技术的办公室、实验室和模块式空间等的设施。大型开放式空间设计为从初创企业到大型机构等处于各种发展阶段的生物技术公司提供负担的起的空间，并激发合作和创新。
中心区域保留了放置凹版印刷机的开放空间。设计利用主楼梯重新规划了曾经放置印刷机的大型区域。双层高实验室位于原来的生产区域，保持了“创新工作正在进行中“的含义。
大楼还为租户提供辅助空间，包括中央玻璃器皿清洗/高压釜区域和“冷冻农场”空间。从四楼的屋顶露台，可将周围风光尽收眼底。
大楼的主要租户是BioSTL，还包含BioGenerator Labs（BioSTL的投资部门）、Confluence Discovery Technologies制药公司、Arch Oncology（一家专注于肿瘤免疫治疗的公司）、Wugen（临床阶段生物科技公司 ）和C2N Diagnostics（阿尔茨海默氏症检测公司）等租户。大楼空间已被全部租赁。圣路易斯华盛顿大学的附属公司BOBB，LLC领导开发了该项目，它同时也是该建筑的所有者。
邓肯大街 4340号项目通过激发合作和创新，成为Cortex科创社区的重要组成部分。Cortex位于美国圣路易斯市中心核心区以西四英里（约6.5公里）处，总占地200万平方英尺（约81公顷）。社区目前拥有超过425家公司以及其6,000名员工，成为了创业者、科技领域从业者、科研机构、跨国企业创新部门等的聚集地，是名副其实的学术、研发、产业、城市相结合的地区经济高价值孵化引擎。
4340 DUNCAN RECEIVES HIGH HONORS IN 2022 INTERNATIONAL LAB OF THE YEAR AWARDS
HOK’s adaptive reuse design repurposed a long-vacant brick warehouse building in St. Louis’ Cortex Innovation Community into a multitenant biotech lab and office space.
The SEFA Lab of the Year Awards recognize teams for creating outstanding laboratory buildings. Recipients are lab projects that excelled in all aspects of project delivery, including planning, design and execution. 4340 Duncan earned “High Honors” in the 2022 competition.
Listed on the National Register of Historic Places, the original 1930 Crescent Building (now 4340 Duncan) was formerly a first-of-its-kind rotogravure printing plant for the St. Louis Post-Dispatch newspaper.
HOK’s design for the adaptive reuse project transformed the building into a state-of-the-art office, lab and modular spaces for biotech companies. Large, open floor plates help enterprises in all stages of development, from startups to large-scale organizations, in need of affordable, functional space to expand and thrive.
A central zone preserves the open space where the rotogravure printers formerly stoo d. The monumental stairs emphasize the original three-story opening that once housed the printer. The two-story lab highlights the area where the production took place, maintaining the sense that “here is where the innovative work is happening.”
4340 Duncan also provides tenants with general support space, including a central glass wash/autoclave area and freezer farm. A roof deck on the fourth floor offers sweeping views.
The anchor tenant is BioSTL, including its BioGenerator Labs, along with Confluence Discovery Technologies, Arch Oncology, Wugen and C2N Diagnostics. One hundred percent of the space is leased. BOBB, LLC, an affiliate of Washington University in St. Louis, led the development of the project and is the building’s owner.
4340 Duncan is making important contributions to the Cortex Innovation Community by sparking collaboration and innovation. Cortex, located just four miles west of downtown St. Louis’s urban core, now anchors a growing regional system of more than 425 companies and 6,000 employees spread throughout 2 million square feet of space.
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